↓ Skip to main content

University of Newcastle, Australia

Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial

Overview of attention for article published in Metabolism: Clinical and Experimental, December 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
1 news outlet
twitter
28 X users
facebook
1 Facebook page

Citations

dimensions_citation
64 Dimensions

Readers on

mendeley
126 Mendeley
Title
Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial
Published in
Metabolism: Clinical and Experimental, December 2017
DOI 10.1016/j.metabol.2017.12.009
Pubmed ID
Authors

Jessica J A Ferguson, Elizabeth Stojanovski, Lesley MacDonald-Wicks, Manohar L Garg

Abstract

Dietary phytosterols (PS) are well-known hypocholesterolaemic agents. Curcumin elicits hypolipidaemic and anti-inflammatory effects in preclinical studies, however, consistent findings in humans are lacking. Concurrent PS and curcumin supplementation may exhibit enhanced hypocholesterolaemic and anti-inflammatory effects to optimise cardio-protection. The objective of this trial was to investigate the effects of dietary intervention with PS with or without curcumin on blood lipids (primary outcome) in hypercholesterolaemic individuals. A double-blinded, randomised, placebo-controlled, 2×2 factorial trial was conducted in hypercholesterolaemic individuals. Participants received either placebo (PL, no phytosterols or curcumin), phytosterols (PS, 2g/d), curcumin (CC, 200mg/d) or a combination of PS and curcumin (PS-CC, 2g/d-200mg/d respectively) for four weeks. Primary outcomes included fasting total cholesterol (TC), LDL-cholesterol, HDL-cholesterol, triglycerides (TG), TC-to-HDL-C ratio (TC:HDL-C). Secondary outcomes included anthropometrics and fasting blood glucose concentrations. Seventy participants with a mean (±SEM) fasting TC concentration of 6.57±0.13mmol/L completed the study (PL, n=18; PS, n=17; CC, n=18; PS-CC, n=17). PS and PS-CC supplementation significantly lowered TC, LDL-cholesterol and TC:HDL-C post-intervention (p<0.05). Reductions from baseline in the PS group were 4.8% and 8.1% for TC and LDL-cholesterol respectively (p<0.05). CC exhibited non-significant reduction (2.3% and 2.6%) in TC and LDL-C respectively, however, the PS-CC resulted in a greater reduction in TC (11.0%) and LDL-cholesterol (14.4%) than either of the treatments alone (p<0.0001). The reduction in the PS-CC treatment was significantly greater compared to those for CC (p<0.05) or PL (p<0.01) alone. Plasma HDL-cholesterol and TG concentrations remained unchanged across all groups. No adverse side effects were reported. The addition of curcumin to phytosterol therapy provides a complementary cholesterol-lowering effect that is larger than phytosterol therapy alone. Implications of these findings include the development of a single functional food containing both the active ingredients for enhanced lipid-lowering and compliance in hypercholesterolaemic individuals.

X Demographics

X Demographics

The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 126 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 20 16%
Student > Master 13 10%
Student > Ph. D. Student 11 9%
Researcher 10 8%
Other 7 6%
Other 14 11%
Unknown 51 40%
Readers by discipline Count As %
Medicine and Dentistry 17 13%
Biochemistry, Genetics and Molecular Biology 13 10%
Agricultural and Biological Sciences 12 10%
Pharmacology, Toxicology and Pharmaceutical Science 7 6%
Nursing and Health Professions 5 4%
Other 12 10%
Unknown 60 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 25. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2022.
All research outputs
#1,506,709
of 25,382,440 outputs
Outputs from Metabolism: Clinical and Experimental
#233
of 3,503 outputs
Outputs of similar age
#34,124
of 448,999 outputs
Outputs of similar age from Metabolism: Clinical and Experimental
#10
of 53 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,503 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 448,999 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 53 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.